Medical

Cardiac regeneration using the hippo signalling pathway

Liver has the ability to regenerate, to overcome the damages caused by alcohol. Not many organs in body can do this, specially the human heart. Research suggest that heart does have the ability to regenerate, because there is something which is powerful and strong enough among ourselves, that is hippo. Heart attack causes irreversible damage to the heart and heart cell dies because they simply can’t breath and they never ever come back which leads to heart failure.

A novel mechanism focused on hippo pathway is a group of molecules work together to control the size of the heart and its growth, except it has a reversible action. In our young age, inner hippo pathways are inactivated, this is why our heart cells grows, expand and vibe. But due to some unknown reason and at some age, hippo pathways are activated. Same thing happens in the animals as well.

This means, we can use hippo pathways to bring back those cells which we thought were dead and gone. Using these cells, a fully functional heart can be created after the occurrence of heart attack. Researcher Kasif Khan in experimental surgical program at McGill University is working on the recreation of heart using hippo pathways.

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Aditya is PhD student department of Geodesy and Geomatics Engineering at the University of New Brunswick Fredericton, Canada. His research area is focused on computer vision and image quality measurements.

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